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All known NTRs bind FG-repeats, typically exhibiting various binding sites dispersed over their surface (Bednenko et al., 2003).
In such circumstances, the MTLD could provide various binding sites as the training sets or testing sets for the development of novel methodologies for comparisons of binding sites.
Theoretical results of MBDC molecules provide the way to predict various binding sites through molecular modeling and these results also support that the chromen substitution is more active in the entire molecule.
A molecular-mechanics potential is used to reconstruct the coordinates of various binding sites with an average root-mean-square error of 0.61 Å and to reproduce known ligand-induced side-chain conformational shifts.
In this section, I shall discuss various techniques that have so far been used to design aptamers targeting various binding sites.
In the C/EBP- β promoter various binding sites allow binding of transcription factors that directly influence transcription of C/EBP- β mRNA (Table 1).
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The chromophore in Q is in a 9- cis configuration, which makes it an untenable candidate for binding to Lys-216 due to steric interactions with various binding site residues.
Cells transfected with luciferase reporter plasmids containing respective binding-sites of various transcriptional factors and Renilla-TK construct were seeded into 48-well plates.
Various miRNA binding sites provide a number of choices which not only meet different needs under various processes but also avoid unwanted cross-reactions.
The nature and distribution of the various receptor binding sites is significant in patterns of control.
ESEfinder prediction suggests loss of various SRp binding sites in the presence of T allele (Additional file 7), thus this SNP could be involved in alternative mRNA splicing.
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