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Templates can be proteins with various binding partners including other proteins (green), peptides (teal), RNA/DNA (brown) or small molecules (red star).
SYNE1 is a spectrin repeat containing protein usually found on the nuclear membrane and is involved in several kinds of protein-protein interactions where it serves as a scaffold and chaperone for various binding partners.
We determined the high-resolution crystal structure of this domain and compared it to known RBD structures from RanBP1 and RanBP2, previously determined in complex with various binding partners.
Beclin 1 has a modular architecture which facilitates differential interaction with various binding partners.
It has been proposed that proteins utilize disordered regions in the adaptive recognition of their various binding partners.
In this study, we performed detailed biochemical characterizations of ANK repeats of ankyrins and their interactions with various binding partners.
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This direct approach allowed the identification of several binding partners that play various roles in the nucleus/nucleolus, such as PAL-1, a transcription regulator, or RPS-16, a component of the small ribosomal subunit.
It is involved in diverse cellular processes and hence possesses various additional binding partners (reviewed in [ 74]).
Here we present the methods used to model the voltage-dependent gating of calcium channels and calcium influx, the binding of calcium to various intracellular binding partners, and the establishment of intracellular calcium homeostasis.
In order to achieve high affinity binding, the Smads associate with various DNA binding partners [ 16].
These hairpins are further processed into a shortened, single-stranded product, and loaded into an AGO protein, and the miRNA associated AGO – together with various protein binding partners – form the functional RISC.
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