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It has, however, been shown that known regulatory elements are not always correctly aligned (Siggia, 2005), an issue that is further complicated by the different alignments produced by various alignment programs (Pollard et al., 2004).
The quality results of our benchmarks of DIALIGN-TX and various alignment programs on the local aligment databases can be found in Tables 1 and 2 for the local protein database IRMBASE 2 and in Tables 3 and 4 for the local DNA database DIRMBASE 1.
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Figure 1 shows not only striking differences in the shape of the distance functions used by various alignment-free programs.
POY may share drawbacks with other automated multiple alignment programs.
Other short-read alignment programs can also be used.
However, pure sequence alignment programs are sufficent here.
Sequences were aligned using the MUSCLE multisequence alignment program.
The sequences of human αB crystallin and other small-heat shock proteins were compared with the sequences of various tubulin proteins for homology using the dot-matrix alignment program 'Dotter' [42].
STAM (Shafrir & Guy, 2004) is a sequence alignment program for transmembrane proteins that accounts for different physical properties at various segments of the protein, while PRALINE™ (Pirovano et al., 2008) combines transmembrane region predictors with membrane-specific scoring matrices to enhance multiple sequence alignments.
Patterns may be aligned to existing alignment marks without exposing the writing area by using the alignment program AL.
Li, R. et al. SOAP: short oligonucleotide alignment program.
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