Sentence examples for various agents targeting from inspiring English sources

Despite being attractive for immunotherapies due to the expression of various tumor associated antigens, the microenvironment in prostate cancer is relatively immunosuppressive and may be responsible for the failures of various agents targeting the immune system in this disease.

As previously mentioned, there are several agents targeted against other pathways and molecules implicated in HER2 resistance that are in various stages of clinical development.

We investigated the possible involvement of intracellular signaling in the pMV-absorption by treating 2C T cells with various pharmacological agents targeting specific signaling molecules (Figure 1C).

Various biological agents targeting T-cells and the inflammatory cytokines are available for systemic treatment of psoriasis.

Recently, various molecular agents targeting the PI3-kinase/PTEN/Akt pathway have been developed including mTOR inhibitors such as everolimus and temsirolimus, and numerous clinical studies are ongoing in endometrial cancer (Oza et al, 2011).

Various classes of agents targeting the PI3K/Akt/mTOR pathway are currently being investigated, including mTORC1/mTORC2 kinase domain inhibitors, mTOR/PI3K dual inhibitors, PI3K-selective inhibitors, and programmed cell death 6 modulators.

Thus 11a could be a suitable lead towards the design of broad spectrum anti-tumor active agents targeting various human tumor cell lines.

Just as combination chemotherapy in general has proven more effective in treating cancer than single agents, it might be wise to employ multiple agents targeting various components of the wound healing and inflammatory pathway to target cancer perioperatively.

Various trials have been performed to assess individualized drugs for the treatment of cancer that target the patients' individual genetic makeup, and numerous agents targeting various cancer-related proteins have recently been developed.

A number of different biologic agents targeting various cytokines are currently available, but few data exist comparing the effectiveness of one biologic agent with another, highlighting the importance and need for comparative effectiveness research (CER) in RA [ 1].

Our findings suggest that a cocktail of agents targeting the various mechanisms for neuronal injury by organophosphates may prove successful.