NLRP3 (also known as NALP3) is activated by a variety of danger signals including viral and bacterial infections and environmental irritants.
NLRP3 is an intracellular pattern-recognition receptor, which responds to a wide variety of danger signals by inducing the formation of a multiprotein complex called the inflammasome, and thereby initiating an inflammatory response.
Signalling through a variety of danger signals, including intracellular pathogen associated molecular patterns (PAMP) and uric acid, results in the association of NLRP3 via its LRR with other members of the death domain superfamily to form a multimeric cytosolic protein complex, known collectively as the inflammasome [ 50, 51].
Studies link narcotic painkillers to a variety of dangers, like sleep apnea, sharply reduced hormone production and, in the elderly, increased falls and hip fractures.
First of all, Daniel and his wife, Nancy, have to avoid a variety of dangers – sharks, hypothermia, drowning – when the plane in which they are travelling to the Galápagos Islands plunges into the sea.
And in recent years, studies have linked narcotic painkillers to a variety of dangers, like sleep apnea, sharply reduced hormone production and, in the elderly, increased falls and hip fractures.
Parkin says Abdullahi's story is not unique, and that migrants face a variety of dangers just trying to get to the Mediterranean from across the many turbulent areas of the Middle East and Africa. .
African-American travelers faced a variety of dangers and inconveniences, such as white-owned businesses refusing to serve them or repair their vehicles, being refused accommodation or food by white-owned hotels, and threats of physical violence and forcible expulsion from whites-only "sundown towns".
Longitudinal qualitative studies place increased demands on researchers who face a variety of dangers, for example, 'burn out'.
This protein complex can be activated by a variety of sterile danger signals (Tsuchiya and Hara 2014).
