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It might occur at the stage of disease initiation: compared with normal Wistar rat, varied copy number of mir-30b and mir-30d in GK might result in altered expression level at some specific developmental stages and at some specific tissues, and the altered expression of mir-30b and mir-30d might then lead to dysfunction of some specific targets, contributing to the development of T2D.
First, homologs of this gene family across the tomato, potato, and pepper genomes were identified, with a varied copy number (from 22 to 40) and a great nucleotide diversity of this gene family was found within species and between species.
This led to a rock-paper-scissor (RPS) like situation that allowed the coexistence of plasmids with varied copy numbers.
A total of 16 protein-coding genes and 2 microRNA genes were prioritized for further analysis (Table S8 and Table 3), which might in combination or alone contribute to the pathogenesis of diabetes on the basis of varied copy number in the genomic level.
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Sequence alignment suggests that miR-513c emerged independently in gibbons, and there are varied copies in great apes and humans.
Transgene copy number varied from two copies (low copy, UCC from 10to2626 months of age) to 48 copies (high copy, UCC from 4 months of age).
We used multiplex amplifiable probe hybridisation (MAPH) to examine whether other members of the beta-defensin family varied in copy number, in addition to those previously described.
This common deletion CNV locus (a CNV region, CNVR [ 10]) was found to vary in copy number; two copies (normal) and one copy (deletion) and spanned 233 kb in the 53 Mb region.
rDNA repeat copy number varied between 300 copies and 800 copies.
For Exchange 1, 14 of the 15 haplotypes display the structure shown in Figure 4; these are similar to Class 1 haplotypes, but vary in copy number from 1 5 copies.
This system allowed us to vary gene copy number through more intermediate levels than previous studies and examine the impact of copy-number variation on growth, cell-cycle phenotype, and response to different cellular stresses.
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