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Scientists have already uncovered several genetic variations that raise risk for ADHD, which is likely caused by a complex combination of genetic and other factors.
While scientists have identified a number of genetic variations that raise the risk for developing different diseases, including diabetes, heart disease, and Alzheimer's, these variants account for only a small portion of the overall risk.
And the massive size of such studies the Wellcome study, for example, included almost 10 billion pieces of DNA gives the statistical power needed for researchers to find genetic variations that raise the risk of disease by a modest amount.
To date, most large-scale studies of the genomics of disease have focused on specific portions of the genome, uncovering hundreds of variations that raise the risk of common ailments, including diabetes, heart disease, and schizophrenia.
The study found, as expected, that gene variations that raise LDL increase risk and those that lower LDL decrease risk.
Those studies found many common genetic variations that raise or lower the risk of various diseases, but only by a small amount.
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They also use sequencing to understand genetic variations that can raise the risk of certain diseases.
By examining DNA from 2,893 men with prostate cancer and 1,781 healthy control subjects, all from Sweden, scientists have found five genetic variations that dramatically raise the risk of the disease.
A wide range of medications -- some newly developed, some that have long been available for other diseases -- will target either the genetic variations that give rise to an individual's cancer (such as the BRCA-1 and BRCA-2 "germline variations" that greatly raise a carrier's lifetime of breast or ovarian cancer) or the genetic mutations observed in the cancerous tissue itself.
Pinker, for example, says that he's unsure if he wants to know whether he carries a genetic variation that dramatically raises his risk for Alzheimer's disease.
A14 SCIENCE/HEALTH Gene Linked to Vision Loss Scientists have identified a genetic variation that substantially raises the risk of age-related macular degeneration, the leading cause of vision loss in the elderly.
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