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In addition, the variations shared by disease samples, whose number can be custom-defined and must be minimum of two, are considered as potential disease-causing genetic variations.
Importantly, some genomic variations shared by distant strains challenge the idea that all clinical strains diverged vertically from a single clone.
In the multiple cases analyses, after filtering by single case module, the variations shared by disease samples are selected and those present in control samples (if they are submitted) are excluded from further analysis.
Other CDS variations shared by several T. whipplei strains encode either hypothetical proteins (9 cases), membrane proteins (1 case), or FtsE, a cell division ATP-binding protein (which had nucleotide changes in the Dig7, DigADP11, Art1, DigMusc17, and DigNeuro18 strains).
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As the first PC accounts for the co-variation shared by all the attributes, this may be a better estimate than the simple or weighted averages of the original variables (Mahloch 1974).
Fisher's team speculated that the variation in sensitivity to bitter tastes was caused by a genetic mutation shared by humans and chimps, and that natural selection had maintained this diversity in both species.
As reported previously, HPV16 molecular variants did not evolve from random mutational events as variation sites and combinations of variations were shared by several isolates and variants [ 25, 26].
Moreover, in light of this overlap, recent studies have shown that multiple gene variations are shared by patients with SLE and patients with DLE [ 10, 11].
The second problem, phenotypic variation, is shared by shRNA depletion and mutant alleles (Waddington, 1942).
The two disease associated mtDNA haplotypes make it possible to identify the SNP responsible for the association by checking the variation(s) shared by then.
Furthermore, while natural variation SNP are shared by multiple individuals and can thus be confirmed through biological replication, most mutations affect a single individual.
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