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Nine variations of the core scaffold are evaluated leading to optimization of the 6 6 core giving compound 48 with an EC50 of 3 nM against wild type HIV infected T-cells.
The UML standard suggests an application of variations of the core notation to model business processes, with existing UML diagrams being applied to model a different view of the business.
In particular, slow time variations of the core field (the secular variation) are the manifestations of the dynamical processes in the outer core.
These discrepancies, due to different approaches in smoothing rapid time variations of the core field, have strong implications for the interpretation of the secular variation.
We sampled more than 10 8) variations of the core LXXLL motif with estradiol-activated estrogen receptor alpha (ERalpha) as a target and found three different classes of peptides.
The former estimated the secular variation produced by the crust by calculating the response of the VIS model to variations of the core field as described by the CM4 model (Sabaka et al., 2004).
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The new model, CHAOS-6, provides information on time variations of the core-generated part of the Earth's magnetic field between 1999.0 and 2016.5.
All the non-synonymous variations of the core-population were listed in Additional file 1: Table S4.
e, f, SNP variation of the core and distributed genes against the Nipponbare RefSeq.
Effects of the variation of the core and over-cladding thickness on the temperature sensitivity of the LPWG formed in the above material are discussed.
The results show that through variation of the core thickness ratio and core strength ratio, the failure mode of sandwich beams could be controlled.
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