A rough map of genomic duplications is available for the B6 strain [74], however no map of the variations of genomic duplications between mouse strains used to construct the F2 crosses is available, and it is not known whether significant variations exist between mouse inbred strains in terms of genomic duplications.
The copy number variation of the duplication unit (ca. 100 kb) has been proposed to underlie susceptibility to HIV.
This suggests that in our set of CEGs, variations in long duplication regions between strains (containing 3 or more CEGs), was not an important factor in giving rise to a significant fraction of the cis-eQTLs.
The results of structural variations and duplication dynamics options are summarized and presented to the user in the form of histograms.
We calculated the strand-specificity, coefficient of variation, duplication rate, gap rate, ribosomal RNA rate, exonic rate, insert size, and GC content of each aligned set of reads [Additional file 4].
Analysing the history of duplication and sequence variation of these antimicrobial genes will help us to understand how selection by infectious diseases has led to functional adaptation at the molecular level.
The removal of segregating variation reveals the influence of additional levels of evolutionary complexity such as variation in duplication rate, which were originally indiscernible.
Our results underscore the need for complete maps of genetic variation in duplication-rich regions of the genome.
The multiple precursors might be a response to complex history of duplication with less or no variation in miRNA sequences.
Minor variations of spa types (deletions or duplications of SSR units) were observed in several isolates within the same ST.
Our results suggest that in Japanese children, copy number variation of the segmental duplication bearing CCL3L1 associates with susceptibility to KD and IVIG response whereas the CCR2-64I-containing CCR5-HHF*2 haplotype is associated with a reduced risk of both CAL development and IVIG resistance.
