While these patients share mostly comparable characteristics with the Pathway CH-1 cohort, and more broadly with patients eligible for SPG stimulation, some variation might exist in actual drug usage.
It was previously suggested that a difference in methylation variation might exist with gender [ 8].
We observed in-del polymorphisms in exon 2 of three chimpanzees, implying that copy number variation might exist in chimpanzees.
However, in other cases, limits to additive genetic variation might exist that would prevent evolution in response to more extreme climate variation.
Although it is possible that β-tubulin class II levels might be correlated with a prognostic bio-marker not yet examined [ 61], these results suggest that a normal patient-to-patient variation might exist.
Third, while our study focused on stages that have previously shown sensitivities to low pH in Atlantic salmon (Daye and Garside 1977; Lacroix 1985), adaptive genetic variation might exist at earlier or later, unexamined life history stages, such as during embryonic development or the parr-smolt transformation (Smith and Haines 1995).
Early versus late surgery, and pharmacological and non-pharmacological interventions for high or low temperature are two examples of the variations that might exist in each institution's 'standard care'.
Although pluripotency induction seems feasible according to this model, it reminds us that a wide variation in pluripotency might exist among different iPS cell lines, which needs to be carefully considered when they are used for research and discovery.
Lastly, although the participating hospitals belong to the same health care system, some variations in laboratory measurements might exist.
By using theory-based model building, we acknowledged the different VA facilities and were attentive to variation in practice that might exist in different geographic regions.
