We are concerned that variation may increase as commissioning is devolved to local commissioning groups.
The results showed that Asp148Glu variation may increase the risk of breast cancer by approximately 3.5-fold in Saudi patients (Table 2).
Subtle functional deficiencies in highly conserved DNA repair or growth regulatory processes resulting from polymorphic variation may increase genetic susceptibility to breast cancer.
Of course, amino acids will vary stochastically in a constant regime of mutation and selection, and modeling such variation may increase the expected variance of the ACE, though the normalization across amino acids should minimize any variance introduced by amino acid substitutions.
Current research in our lab is exploring protocol variations that may increase effects on the clinically-relevant behavioral endpoints.
Sex usually increases genetic variation and may increase the rate of evolution.
The risk of pathogen-specific allelic selection could determine undesired loss of MHC variation, which may increase susceptibility to other pathogens.
Large populations may also benefit from some hybridization when experiencing environmental change; the increased genetic variation generated may increase the capacity to respond to new selective pressures (Swindell and Bouzat 2006).
This coding polymorphism is also associated with thromboxane levels, suggesting that genetic variation in PLA2G4C may increase risk for preterm birth by increasing levels of prostaglandins, which are known to regulate labor.
