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Our objectives were to examine the extent of described sequence variation in the glucose transporter 3 (gene3) gene in children with myelomeningocele (MM), identify novel variations in the GLUT3 gene in these children, and determine whether these variations may confer a risk of MM.
Since more extensive genetic variations may confer a phylogeny closer to the true one, the total of 265,487 SNPs in the SAP were used to analyze population structure.
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Whether sequence variation may confer disease susceptibility is also not known.
Many of these coding sequences are associated with simple sequence repeats (SSRs), indicating that phase variation may confer the potential for antigenic variation and immune response evasion during infection.
We hypothesized that COMT variation may confer a general risk for psychiatric disorders and have genotyped four COMT variants (Val158Met, rs737865, rs165599, and a SNP in the P2 promoter [-278A/G; rs2097603]) in 394 Caucasian cases and 467 controls.
However, it remains elusive whether 2q37 deletion per se or other genetic factors, such as copy number variations (CNVs), may confer the risk for the tumorigenic condition.
Till now, many epidemiological studies suggested genetic variations in APE1 may confer individuals' susceptibility to cancer.
Coding variation in CPA4 may confer increased risk of intermediate-to-high risk prostate cancer among younger patients.
Thus, mutant LRRK2 may confer pathogenic effects through other functions.
This Notch-dependent competition among neighboring cells may confer variations to the fate of daughter cells that inherit a full epithelial structure at apical divisions.
It has also been hypothesised that variations in isoform expression may confer differential advantages on tumours as they expand in the different sites, each of which may possess different requirements for neovascularisation (Grunstein et al, 2000).
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CEO of Professional Science Editing for Scientists @ prosciediting.com