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The main findings of this study were: 1) the bioinformatics approach proved successful in identifying putative candidate genes, 2) the variations in the selected candidate genes were associated with several NAFLD-associated traits, suggesting a potential role in the development of these metabolic phenotypes.
The main variations in the selected compounds were the substituent groups in the N1 and N2 positions of the indazole (R1) and the groups in the 3-position of the oxadiazole, which included tert-butyl carbamate and free-amine groups (R2).
This component explained 31% of the variations in the selected 11 indicators.
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The elevated sensitivity develops as a logical consequence of re-ranking GxE interaction and/or when genetic variation in the selected environment is higher than in the non-selected environments.
If the population harbors additive genetic variation in the selected traits, then the population can respond to this selection, causing the mean and variance of those traits to change across generations (see Marnocha et al. 2011 for an example with island lizards).
The final conservation at each position in the selected conserved regions was higher than it appears in Table 1 and 2, as the variation in the selected regions, between subtypes often resulted in similar substitutions.
The resulting PCA score plot is shown in figure 3, with the two first PCs explaining 55.65% of the variation in the selected metabolites.
A central challenge for interpretations of otolith chemistry is identifying the source of variation in the selected elemental or isotope markers [40].
When a target species is misidentified during testing, it is usually an indication that the degree of variation in the selected images does not adequately represent variation in the taxa.
For decades, epidemiologists have used the term "effect modification" in a broad context, simply referring to a variation in the selected effect measure for the factor under study across levels of another factor [ 49].
The nearness of other pollutant sources such as a floodway stream and a domestic sewage outlet might be related with the space time variations observed in the selected parameters.
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