The three recurrence regions were homogeneous at the SNV level indicating limited clonal variation in the recurrence; however, the SNV calling was hampered by stromal contamination (supplementary Table S1, available at Annals of Oncology online).
Neither variations in the rate of recurrence (0 12 %) nor the baseline rate of bilateral disease (0 30 %) affected the dominance of ranibizumab over vPDT.
Previous studies report wide variations in local recurrence rates and randomised or matched cohort study designs are lacking.
Variations in recurrence rate, utility value, QALYs, the acquisition cost of S-1, recurrence cost, end-of-life cost, and simulation model did not greatly change ICER.
Parker et al 6 in 1999 reported a survey of clinical geneticists, in which they noted a great variation both in the services provided and in the recurrence risks quoted in isolated cases of childhood deafness.
For the current sequence of reliable Nankai Trough earthquakes, there have been large variations in the magnitudes (M w = 8.0 8.7) and recurrence intervals (90 262 years) of successive Nankai Trough earthquakes, with different rupture extents along the Nankai Trough.
The results of one-way sensitivity analyses are shown in Table 4. Variations in recurrence rate, utility value, QALYs and the acquisition cost of UFT did not influence the dominance of UFT therapy.
Variations in the values of other input parameters (monthly probability of recurrence, probability of requiring top-up treatment and probability of receiving a 2nd interventional treatment) only had minor effects on the model outcome.
This was further confirmed in the recurrence map where consecutive cycle lengths had a periodic long/short variation.
The relationship between inherited germ-line variations in the 5α-reductase pathways of androgen biosynthesis and the risk of biochemical recurrence (BCR) after radical prostatectomy (RP) remains an unexplored area.
