Sentence examples for variations in potency from inspiring English sources

Virtually all of these cannabinoids bind to the CB1 receptor in the brain, but beyond that there are enormous variations in potency, functional activity, off-target binding, and an enormously diverse population of users taking different doses often in combination with other drugs.

Large variations in potency are found within the list of compounds that were tested.

These differences may account for some of the observed variations in potency, disease-specific efficacy, safety patterns, and speed of onset and offset of action (Russell 2007).

This allowed the estimation of full concentration response curves without needing to extrapolate to untested effect levels. Figure 2 shows the concentration response curves for each chemical plotted on the same concentration scale, thus highlighting the magnitude of variations in potency.

Several promising antimicrobial lead compounds targeting LpxC have been reported, though they typically display a large variation in potency against different gram-negative pathogens.

Also due to the fact that compounds of this substructural class were documented as adenosine receptor ligands [36], computational SAR studies were focused on the PDE10A data, where the variation in potency was rationalized in relation to the physicochemical properties of the compounds (which were computed by FAFDrug3, Additional file 1: Table S1) [40].

Although the basis for the difference in potency between Stx1 and Stx2 is unclear, the B-subunit plays an influential role in mediating toxicity [21] [25], suggesting that differences in B-subunit activities, such as receptor recognition or toxin internalization, are responsible for the variation in potency.

Azoxymethane (AOM) can show lot-to-lot variation in potency, and will lose potency and gain toxicity over time.

The insulin being produced at this time was inconsistent, with wide batch-to-batch variation in potency [ 20].

The experiments were performed with a range of RecX concentrations to explore the variation in potency between the mutant and wild-type proteins.

In contrast, 2,6- and 3,5-DMA both induced cell death, but exhibited considerable variation in potency, in which the aminophenol metabolites were considerably more potent than the corresponding N-hydroxylamines.