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GNPs smaller than 8 nm (3 and 5 nm) or larger than 37 nm (50 and 100 nm) did not induce significant KC variations in mouse livers.
BA concentration and composition exhibit circadian variations in mouse liver and serum, which influences the circadian rhythms of BA metabolizing genes in liver and ileum.
Identifying the genetic basis responsible for phenotypic variations in mouse models is most successful when using dense SNP panels and phenotypic measures across several laboratory strains.
The degree of EMT contribution to renal fibrosis may differ depending on the myofibroblast markers used or genetic variations in mouse strains in susceptibility to renal injury [ 20, 24, 25].
10 21 The background ambiguity of these mice leaves open the possibility that formerly observed differences in α-defensin expression may be due to variations in mouse strain between experimental groups, as opposed to a true effect of Nod2 deficiency.
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The complexity of allelic variations in mice generated by such Cas9 gRNA embryo injections requires detailed genotype analysis (addressed below).
On the other hand, the expression of many genes, including the TH gene and other genes related to monoamine neurotransmission and drug responses, shows important interstrain variations in mice, affecting particularly their expression in cells of higher order centers of the forebrain, such as the striatum (Morris et al. 2010).
Specifically, clock but not cycle shows diel variations in expression in the fruit fly, whereas bmal1 (the mammalian ortholog of cycle) but not clock shows diel variation in mouse [15].
The prototype prion disease is scrapie in sheep, and whereas Prnp exhibits common missense polymorphisms for V136A, R154H and Q171R in ovine populations, genetic variation in mouse Prnp is limited.
Why so much intraspecific variation in mouse lemur pelage coloration exists at Beza Mahafaly is unknown.
The mRNA expression of drug-metabolizing enzymes showed circadian variation in mouse tissues.
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