Sentence examples for variations can alter from inspiring English sources
Indeed, changes in the relative position of genes and regulatory elements by chromosomal rearrangements and structural variations can alter gene expression with dramatic consequences [ 36- 40].
At least 15% of human disease-causing mutations occur at splice sites [ 16]; mutations and genetic variations can alter the splice site signals and splice regulatory elements to mediate formation of alternate transcripts and protein isoforms [ 17- 20].
This variation can alter the overall appearance of the tree, canopy shape and branch size, the relative shape and size of the leaves, and their colour and stiffness.
One mechanism by which disease-associated DNA variation can alter disease risk is altering gene expression.
Genetic variation can alter transcriptional regulatory activity contributing to variation in complex traits and risk of disease, but identifying individual variants that affect regulatory activity has been challenging.
The complement of these organisms varies by individual within a species, and this variation can alter host phenotypes, a fact that makes understanding the diversity and function of these organisms of more than ecological interest.
Here we describe two germline genetic variations that can alter in vitro enzyme function of pol ι in nucleotide incorporation with normal and lesion DNA substrates, as well as DNA substrate binding.
The ELISpot assay is a widely used method for detecting T-cell responses to antigens of interest, but variations in protocol can alter the results obtained.
These CpG sites are common in regulatory DNA sequences, so variation in methylation can alter gene expression, which potentially alters expression of observable characteristics (phenotypes) without actually changing gene sequences.
The low-affinity FcγR genomic locus is complex, containing regions of copy number variation (CNV) which can alter receptor expression and leukocyte responses to IgG.
It has also long been known that intraspecific genetic variation in plants can alter ecological community structure; for example, in 1960, De Wit reported that the reproductive output in mixtures of the grass species Anthoxanthum odoratum and Phleum pratens depended on associations of particular genotypes (De Wit, 1960; Allard and Adams, 1969).
