Sentence examples for variations at conserved from inspiring English sources

Based on our observations, we suggest that conserved residues along with residue variations at conserved positions form the basis of TR selectivity and specificity.

This is likely the reason for the observation that the use of EM for our data did not distinguish between residues harboring disease-associated and neutral variations at the conserved positions (see Methods).

Since variant amplification, sequencing and variant calling does not use any information on cross-sectional conservations, the absence of variation above 1% at conserved sites is further evidence that our amplification and sequencing pipeline does not generate spurious variation.

Mutations at conserved sites between LATS1/2 such as LATS1-F1015/LATS2-F978, R1020/R983, F1039/F1001, and D1086/D1048 may affect function of the C-terminus.

About 11 12% of the NB tumors were shown to carry non-synonymous sequence variations in conserved positions of the tyrosine kinase domain.

Rapid reversion at conserved sites.

They also found that MECP2 mRNA levels in peripheral blood mononuclear cells of four patients with variations in conserved sequences were significantly lower than that of controls, suggesting that changes in at least these conserved sequences may alter mRNA stability and, thus, protein expression levels.

Under translational selection for accuracy one may hence expect higher optimal codon frequencies at conserved than at non-conserved amino acid sites.

The analysis showed the extremely conserved structure of chloroplast genomes with surprisingly little variations at the LSC/IR and SSC/IR boundaries.

Here we have used a combined computational and experimental approach using ALRQ, AFRQ, and ALHQ ovine PrP in order to determine how genotypic variation at amino acid residues 141 and 154 influences conformational variation in conserved regions of ovine prion protein variants associated with susceptibility to atypical scrapie.

The evolutionary variations of these conserved secondary structures in human populations and their biological functions have not been fully studied.