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He was the creator of a monastic rule that, through constant variations and modifications, became authoritative for later Orthodox monasticism.
In the postfiltering scheme, the Wiener filter based on the mean-square-error (MSE) criteria [30, 31] is often the starting point for variations and modifications, e.g., [32 34].
This type of comparative (semi-quantitative) analysis enables correlations to be drawn between the range of proteins, their variations and modifications produced by a cell, tissue and biofluids and the initiation, progression, therapeutic monitoring or remission of a disease state.
The number of variations and modifications of the blind bedside technique attest to the fact that none is ideal.
The principles of the methods were first conceived by Gibbs as early as 1933 [ 1] and many variations and modifications have been proposed since.
Meanwhile, the LCS network is very dynamic, demonstrating significant variations and modifications on the pericellular fluid annulus around each canalicular connection or lacunar node.
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The results form a basis for determining parameter variations and design modifications to improve performance and fuel utilization.
Other kinds of genetic variations such as rare or even individual SNPs, copy number variations and epigenetic modifications though maybe equally important, have not yet been targeted.
Collectively these observations suggest that genetic variations and epigenetic modifications in the Qki promoter region might not be the major determinants responsible for reduced Qki expression that is associated with human diseases such as schizophrenia, depression and cancers.
Further progress is expected now that the important role of other forms of genomic polymorphisms between individuals, including monozygotic twins, has been recognized; these include the effects of copy number variations and epigenetic modifications [ 168- 170].
However, it has been debated to what extent expression variation and epigenetic modifications, such as patterns of DNA methylation, are transferred across generations, and therefore it is uncertain what role epigenetic variation may play in adaptation.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com