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Overall, such differences in the propensity for DIO could be due to both epigenetic variations and genetic predispositions, especially because our rats were derived from closed colonies of genetically variable composition.
Large-scale systems biology meta-analyses of GWAS results can improve interpretations of genetic variations and genetic risk factors.
Understanding the structural change in the genome, as well as its functional impact, is critical for studying phenotypic variations and genetic diseases in human and model organisms (Korbel et al., 2007).
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We found genetic variation and genetic variation in plasticity for both chemicals but not for growth rate.
Resequencing a key germplasm subset representing various geographically distributed populations can provide scientists with in-depth knowledge of the range of genome variation and genetic diversity within the population based on sequence databases.
In addition to reduced genetic variation and genetic drift, local adaptation can also be constrained by variation in natural selection and gene flow [1], [12].
Evolutionary studies on the morphological variation and genetic divergences of insular biotas are mainly based on extant species.
As a first step in applying functional genomic analysis to population studies, we have examined the relationship between gene expression variation and genetic variation in a central molecular pathway (NRF2-mediated antioxidant response) associated with smoking exposure and lung cancer.
Allele variation and genetic diversity were obtained with POP100GENE (table 1 and Fig. 3).
Mutations also introduce novel variation and genetic drift affects neutral allele frequencies, especially in small populations.
8 The most popular approach for analyzing sequence variation and genetic clustering is the phylogenetic analysis.
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