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The current Wm82_v2 reference genome alone cannot provide conclusive answers to questions regarding large structural variations and complex genomic rearrangement.
Genome-wide exploration of variation identified abundant SNPs, insertions and/or deletions (indels), structural variations and complex segmental duplication patterns within the sequenced population of the Fuzhou-S strain (Fig. 1, Supplementary Figs. 8 and 9, Supplementary Tables 9 13 and Supplementary Note).
Extreme temperatures, pH variations, and complex oral flora have made the oral environment a unique media [13] that cannot be simulated in experimental conditions [8].
In spite of the conduct of extensive studies in search for genes causing complex diseases, connections between DNA variations and complex phenotypes, which are essential for unraveling pathogeneses of complex diseases and predicting variation in human health, have remained elusive.
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Genome-wide association studies (GWAS) were designed to investigate the association between common genetic variation and complex human traits using high-throughput platforms that measured hundreds of thousands of common single-nucleotide polymorphisms (SNPs).
In turn, this will enable us and to focus on candidate haplotypes whose allelic differences in expression may provide an important link between individual genetic variation and complex traits or common diseases.
These effects were most pronounced in experiments with large biological variation and complex hybridization designs.
Knowledge of the complete haplotype structure of KIR is critical for association studies between KIR genetic variation and complex diseases.
Since most of the important agronomic traits are complex inherited traits, transcript abundance may act as an intermediate phenotype between genomic DNA sequence variation and complex traits.
Moreover, these studies effectively have demonstrated how gene expression microarrays can help close the information gap that exists between DNA variation and complex diseases.
By providing an integrated set of tools, it offers plant biologists and geneticists a way of exploring the relationship between genome variation and complex forms of phenotypic variation (4 7).
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