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Pathway: Search can be carried out for the variations affecting a gene featured in a specific biological pathway.
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GO term enrichment for biological functions was performed as previously reported [46], in order to determine whether the observed inter-group variations affected a functional cluster of proteins sharing similar biological and molecular functions, or co-localizing in a sub-cellular compartment.
It was found that the genomic variations affect a total of 227 proteins of Px strain and a quite number of mutations alter key enzymes in the central carbon and nitrogen metabolism and in the biosynthesis of secondary metabolites, which probably results in the redirection of common precursors for erythromycin biosynthesis [ 53].
In this study, we aimed to systematically uncover and characterize genome-wide variation affecting a major metazoan process.
DNA copy number variations (CNVs) are an important component of genetic variation, affecting a greater fraction of the genome than single nucleotide polymorphisms (SNPs).
With regard to adequate methods for investigating person-situation interactions, most of the existing approaches analyse by way of analysis-of-variance or via multivariate regression analysis how dichotomous situational variations affect an outcome variable that depends on individual characteristics (Cronbach and Snow 1977; Carver and Scheier 2008).
The second group corresponds to tumors from the clusters a and f for which it is not possible to identify a copy number variation affecting an entire chromosome arm, either because of a flat profile (cluster a) or because of a huge number of DNA breakpoints (cluster f).
These indices allow one to know how much a variation affects a given plan.
When it comes to the permanence of a population, safety is not always in numbers because environmental variation affects a population regardless of its size.
It is possible that DTNBP1 variation affects a common pathway involved in anxiety and addictive disorders.
Using systems genetics approaches, our study demonstrates how genomic sequence variation affects a unique regulatory network that is associated with macrophage multinucleation in the rat.
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