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The FDA changed the drug's label in 2007 to note that two specific genetic variations affect a patient's sensitivity to the drug, but broad gene testing has not yet caught on.
It was found that the genomic variations affect a total of 227 proteins of Px strain and a quite number of mutations alter key enzymes in the central carbon and nitrogen metabolism and in the biosynthesis of secondary metabolites, which probably results in the redirection of common precursors for erythromycin biosynthesis [ 53].
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Reverse causation investigations have the opposite structure from A/B tests, in which we vary known causes, and observe how the variations affect an outcome.
With regard to adequate methods for investigating person-situation interactions, most of the existing approaches analyse by way of analysis-of-variance or via multivariate regression analysis how dichotomous situational variations affect an outcome variable that depends on individual characteristics (Cronbach and Snow 1977; Carver and Scheier 2008).
GO term enrichment for biological functions was performed as previously reported [46], in order to determine whether the observed inter-group variations affected a functional cluster of proteins sharing similar biological and molecular functions, or co-localizing in a sub-cellular compartment.
Pathway: Search can be carried out for the variations affecting a gene featured in a specific biological pathway.
These indices allow one to know how much a variation affects a given plan.
When it comes to the permanence of a population, safety is not always in numbers because environmental variation affects a population regardless of its size.
It is possible that DTNBP1 variation affects a common pathway involved in anxiety and addictive disorders.
In this study, we aimed to systematically uncover and characterize genome-wide variation affecting a major metazoan process.
DNA copy number variations (CNVs) are an important component of genetic variation, affecting a greater fraction of the genome than single nucleotide polymorphisms (SNPs).
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