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b Result variation with mutation percentage for JAYA.
Open image in new window Fig. 5 a Result variation with mutation percentage for TLBO.
Owing to space limitations, we present the co-occurrence matrices for 2012 in Supplemental Material 7. Similar patterns of hot spots and co-occurrences were observed between years with only minor differences, all except for the notable change in co-occurrence of variation with mutation and not with heritability.
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Partitioning the sites into groups according to ancestral amino acid identity explains some of the variation, with mutations at certain amino acids being unconditionally deleterious, others unconditionally nearly neutral, and others with substantially variable effects.
A study of 25 breast cancers revealed diverse patterns of mutation, with a variation in the number of mutations and in the identity of mutated genes, such that no commonly point-mutated kinase gene was identified [10].
As mentioned above, SNP-containing motifs, which potentially regulate genes with genetic variations and mutations, link information from SNP array and gene expression array.
In this study, we associated SNP array data and gene expression array data to evaluate genes with genetic variations and mutations that may be the causal mechanism for different RNA expression profiles.
Given the apparent importance of defects in translation and in particular in translation repression [ 7, 38], increased exposure to sodium azide might contribute to the observed increased prevalence of ASD synergistically with rare synonymous variations and mutations impairing translation, even without an increase in the rate of such variations/mutations.
Such variation may be associated with mutations in the antigenic epitopes or other parts of the NoV genome [ 25, 28].
Even within these groups, there is great variation in phenotype of patients with mutations in the TH gene.
Thus, pinpointing the key alterations (driver mutations) from a background of variations with no direct causal link to cancer (passenger mutations) is difficult.
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