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A highly interesting variation was recently listed in the MITOMAP unpublished variant database.
A third major variation was recently presented by Lewington et al (2009) in a large group of neuroblastoma patients treated in the high-risk neuroblastoma SIOPEN study (method 3; 'SIOPEN'SIOPEN
Normal facial variation was recently analysed on a complete sample of 4747 faces from the ALSPAC database and the same number of PCs was extracted, with an almost identical order of individual PCs and very similar percentages of variation.
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C-reactive protein (CRP) gene variation, in particular an rs2794521 variant was recently associated with type 2 diabetes mellitus (T2DM) in Pima Indians.
Intriguing is that CDKN1C gain-of-function variations were recently found in patients with IMAGe syndrome (intrauterine growth restriction, metaphyseal dysplasia, congenital adrenal hypoplasia, and genital anomalies).
These genomic variations were recently found to be widespread, encompassing 5% of the human genome [ 9], and are thought to be involved in (co determining complex phenotypes [ 10, 11].
It is also possible that the very process of laboratory domestication has artificially shaped pheromone receptor content or variation, as was recently demonstrated in C. elegans[ 39].
The basis of genotype-specific variation in recalcitrance was recently identified in the fast-growing biomass crop willow (Salix sp).
The ahl4 locus, which could explain about 40% of the ABR threshold variation in these mice, was recently identified as a mutation in the gene of Cs (Noben-Trauth & Johnson, 2009; Johnson et al., 2012).
However, the model by which mutational biases drive variation in nucleotide content was recently driven out of favor by the discovery that mutation is universally AT-biased even in prokAT-biased eveninhly GC-rich genomes (Hershberg and prokaryotes; Hildebrand et al. 2010).
A change in quantal size could result from either pre or postsynaptic mechanisms [7] – variation in mEPSC size was recently shown to depend on vesicular glutamate concentration [8].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com