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The vast majority of the observed variation was predicted to have no impact on the efficaciousness of a protein vaccine incorporating a single variant of SP0148, SP1912 and/or SP2108 from S. pneumoniae TIGR4.
Multiple allelic variants of these proteins were identified, different allelic variants dominated in different continents; the observed variation was predicted to impact the antigenicity and structure of two SP0148 variants, one SP1912 variant and four SP2108 variants, however these variants were each only present in a small fraction of the global population (<2%).
This yielded SNP-motif pairs for which genetic variation was predicted to influence TF binding.
Genetic variation was predicted to occur along latitudinal and elevation gradients (Figs 1C and S6B).
Using the PolyPhen analysis tool, the variation was predicted as "probably damaging" to protein function.
Less variation was predicted for oxidative metabolism (5-fold range across strains) compared with glutathione conjugation (10-fold).
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Subtle effects of Mn content variation were predicted for the energy spectra of the P b1−xM n x Se dots, whereas important consequences are expected for P b1−xM n x Te dots.
In insect societies, intracolonial genetic variation is predicted to affect both colony efficiency and reproductive skew.
Finally, transport current distributions and thereby cell-to-cell variation were predicted using the saturation model.
Finally, we identify SNPs at which variation is predicted to influence binding of these TFs.
If negative epistatic interactions are important in maintaining reproductive isolation, specific patterns of genetic variation are predicted in hybrid genomes.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com