Sentence examples for variation transcript from inspiring English sources

These results demonstrate a link between genomic sequence variation, transcript abundance, protein level, and enzymatic activity.

For example, due to the genetic as well as environmental and developmental sources of variation, transcript level variation at a gene locus underlying a QTL is highly associated with the total phenotypic variation in the actual quantitative trait [ 38].

Note that environmental or developmental fluctuations may be ruled out as explaining these patterns of co-variation: transcript level measurements in each heterozygous genotype were biologically replicated to account for dye and environmental effects.

Although deep-sequencing experiments have become the major source supporting microRNA annotations, technical variations, transcript length bias and mapping bias have been reported with this approach for transcriptome analysis of coding RNAs (mRNAs) [ 17, 55, 56].

We developed and applied a variety of bioinformatic analysis algorithms to identify the sequence and expression variations (transcript polymorphisms) among the genotypes, and further predicted their effects on gene function.

The generally high heritability of these transcripts suggests that selecting transcripts whose inter-individual variation in transcript levels is greater than their intra-individual variation, identifies transcripts whose regulation has a strong genetic component.

In contrast to alternative transcriptional initiation, no convincing examples of transcription factor genes with variation in transcript end as the sole mechanism for generating alternative transcripts were found.

Several of the candidate sRNAs showed variation in transcript concentration during growth, with transcripts decreasing in abundance during stationary phase in most cases (Figure 2).

It suggests that allelic variations contribute to transcript variation more in invertebrates and plants than in vertebrates, while alternative splicing plays a major role in vertebrates.

In order to normalize the natural variation of transcript levels between different embryos, pooled data from separate experiments were z-scored prior to pooling.

Inferring regulatory relationships among many genes based on their temporal variation in transcript abundance has been a popular research topic.