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Unexpectedly, the sequences showed great conservation and there was not sufficient variation to answer this question.
However, these loci may be difficult to align, they may lack sufficient variation to answer many questions, and they may not reflect the full complexity of the organismal history (McDaniel et al., 2010; Vanderpoorten and Shaw, 2010).
The ability to develop genomic resources for nonmodel organisms greatly improves our ability to use naturally occurring variation to answer important questions in evolutionary biology (Martin et al. 2012; Domingues et al. 2012).
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For instance, the narrator of "The Gold Bug Variations" is trying to answer a human conundrum: Why did Dr. Ressler abandon, in the late nineteen-fifties, a brilliant early career in genetic research?
Let's Have Some Fun Right Now Over the years, Stanford University has asked applicants to answer some variation of a "Letter to your future roommate" essay question, e.g., "Virtually all of Stanford's undergraduates live on campus.
Students commonly have misconceptions about how mutations affect phenotype and questions that address the origins of variation are challenging for them to answer correctly (Gregory, 2009).
She particularly stressed the importance of experimental design, of sample size and replication, of understanding sources of variation, of ensuring quality data to answer questions of interest, and of new computational methods to analyze large datasets.
Reference genome sequences and high-throughput data analysis also provide the basis for resequencing whole genomes or transcriptomes to answer questions about variations between cultivars, populations, and taxa.
Or, in other words, the F-test was used to answer the question whether variation in plaque size was merely an artefact or whether it was related to the use of antiviral drugs.
What this study was not designed to answer is whether the variation in protocol-sharing units leaves gaps, i.e. CAMHS/AMHS interfaces that are not covered by agreed protocols, or whether the variation is a result of trying to cover the gaps.
Experiments suitable to answer a few circumstantial variations in cause-effect relations are described in the chapter.
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