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Copy number variation (CNV) has been proposed as one other type of genetic variation that contributes to phenotypic variance.
We find considerable overlap between the genetic variation that contributes to normal menopause age and EM.
Mouse models are an invaluable tool for identifying allelic variation that contributes to genetically determined differences in physiology and behavior.
Pharmacogenetics is the study of the genetic variation that contributes to inter-individual differences in drug response and propensity to side effects (Roses, 2000).
Therefore, identifying such regions will allow us to detect genetic variation that contributes to phenotypic diversity and facilitate functional annotation of the genome.
Thus a GWAS is inherently searching for genetic variation that does not fit the model of a rare mutation leading to disease; rather it is searching to identify common genetic variation that contributes to the risk for disease.
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These three QTL also explained a significant proportion of phenotypic variation that contributed to reduced levels of root rot and lesion size.
He argued that most sites of variation that contribute to disease are rare (<0.1% frequency in the population), recent in origin within a family lineage, and under strong negative selection.
It has been estimated that common variants within GWAS conducted by the Genetic and Environmental Risk for Alzheimer's disease (GERAD) consortium (8) account for ∼24% of the estimated heritability of AD (Lee et al., submitted for publication) and so other sources of genetic variation that contribute to the disease remain to be identified.
TRs have orders of magnitude higher mutation rates than point mutations and TR allele states are reversible, two attributes that are often viewed as advantageous when TRs are compared against other standard sources of genetic variation that contribute to evolution (King et al. 1997).
But recent genomic studies have identified several genetic variations that contribute heavily to the disease.
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