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The justification for this was that as genomic sequences diverge, the sequence variation span in binding sites under negative selection might not be fully captured by a PWM, which focuses on the "center" of the nucleotide distribution.
What genomic region does this copy number variation span?
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Fossil pollen and charcoal analyses of sediments from Lake Titicaca, Peru/Bolivia, provide a record of palaeoclimatic variation spanning four full glacial cycles.
Moreover, for many of the genes in both data sets, the variation spans nearly the entire range.
The FMT is a widely used color vision test that requires participants to sequence color reference caps in order of incremental hue variation spanning the visible spectrum.
Having read the article, a user may be interested in finding out more about a particular structural variation, such as the size of the genomic region that a particular structural variation spans.
To acheive a thorough assessment of the accuracy of bisulfite-based profiling on pooled DNA samples it was desirable that we selected regions demonstrating considerable between-individual variation spanning a range of DNA methylation levels from unmethylated to fully methylated.
However, if allelic variation spans species boundaries, i.e., if some alleles of a species are more closely related to alleles of another species than they are to those of the same species [ 64], such a variation might confuse the identification of the allopolyploid's progenitors.
Human diseases are caused by alleles that encompass the full range of variant types, from single-nucleotide changes to copy-number variants, and these variations span a broad frequency spectrum, from the very rare to the common.
As well as the long-term downward trend, there are strong variations spanning a few years or a few decades.
The dark-blue curve exhibits the historical geomagnetic variations spanning the past four centuries estimated at Paris by Thellier (1981) from a selection of D, I measurements from Paris, London and Rome.
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