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These observations lead us to seek mechanisms by which the MYH9 variation reported here could exclusively or primarily affect the kidney.
Recent work, however, suggests that mutational hotspots also occur in coding regions of the mtDNA [ 31] making the high variation reported here for ATPase genes somewhat less surprising.
The VR variation reported here may also explain conflicting reports in the literature about the effectiveness of some putative pheromones [ 59].
Authors have made an attempt to study the mechanisms by which the MYH9 variation reported here could exclusively or primarily affect the kidney.
Much of the between-animal variation reported here reflects functions that are sensitive to environmental cues, such as androgen response, circadian rhythm, and immune response.
One of the most puzzling aspects of the genomic variation reported here is how gene regulation takes place in such a variable genomic landscape.
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Therefore, the status of the copy number variations reported here is in relation to the reference sample.
However, to support an argument for their potential evolutionary contributions to cattle domestication, breed formation and adaptation, the genomic variations reported here need to be queried in a larger sample size and with breeds other than Holstein.
The new mutation reported here should be added to the long list of pathogenic variations described in the PYGM gene.
The longitudinal variation in ρg reported here is consistent with previous research within mature P. radiata stems (Chan et al. [2012]; Cown and McConchie [1982]).
Confidence intervals are designed to reflect sampling variation and rates reported here are based on all incident strokes within a population.
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