By use of the PCA we first arrived at 13 principal components (as each barrier got scores for 14 functional limitations), that accounted for the total variation of the scores across the functional limitations.
The inter-observer variation of the mean score of "erosions", "ulcerations" and endoscopic activity index in mild disease, and the scoring of "erythema" and "oedema" in moderate-severe disease was significantly higher in the inexperienced group.
To this last end, we introduce the use of the total gain and partial total gain to quantify recognition and early recognition of active compounds attributed to the variations of the scores obtained with virtual screening methods.
8 We implemented the T5, F p, V T, and T max variations of the SCORE-TEST for the analysis of the simulated and real datasets, but for brevity, we present only the results of the T5.
Variations of the scoring function in (4), for example, by median centering rather than mean centering or by optimizing the homogeneity of interaction frequencies instead of total frequencies, can be explored to test the robustness of the enrichments described here.
These variables explained 16% of the variation of the MIDAS score (p=0.001; r [2]=0.16).
As was the case with the Scripps IC50 data, there is no appreciable difference between the BCI and the FCFP_6 models apart from the much larger variation of the ROC score for the BCI model.
Firstly, there may be interobserver variation of the Gleason score between general pathologists and uropathologists.
We also calculated a variation of the BDS score that considers only W→S and S→W substitutions.
