Sentence examples for variation of kinase from inspiring English sources

The clinical significance of non-codon 600 mutations remains unclear, in part, due to variation of kinase activity for different mutants.

The role of BRAF mutations in the MAPK pathway is complicated not only by the multiplicity of signaling molecular components but also the variation of kinase activity for different BRAF mutants (Fig.  1).

The rate of phosphorylation due to kinase E is given by V E [ E ] [ S ] h / ([ S ] h + K E h ), which acknowledges variation of kinase concentration [ E] and permits kinase-specific response profiles, parameterized by K E and h, with rate constant V E. Below, the Hill coefficient h is taken equal to 1 (non-cooperative binding).

In contrast, within the filamentous Ascomycota (subphylum Pezizomycotina) and the Basidiomycota groups, the variation in terms of kinase number is much higher.

Plk2 4 display varying roles in cell cycle progression: Plk2 plays a role in centriole duplication;[52] Plk3 is a non-cycling Plk[53] involved in G2 checkpoint signaling.[54] Plk4 differs from Plk1 3 as it contains a variation of the Plk kinase motif and has a single polo-box.[55] Plk4 has been shown to localize to centrioles and, like Plk2, is thought to be important for centriole duplication.

But unlike the K1 models where variation of Sig + kinases' concentration resulted in two fold decrease in robustness as compared to kinases' concentration variation with constant Sig (Compare Figure 2A and 2C), the K2 models showed very little change in MK-PP robustness while subjected to such perturbations (Compare Figure 3A and 3C; Figure 3B and 3D).

This ErbB3-specific variation may contribute to the low levels of kinase activity [17] by preventing opening and closing motion during catalysis.

One of the remaining motifs ("V.[STP]P") contains a serine/threonine residue and may constitute a new phosphorylation site or a variation of the known cyclin-dependent kinase motif.

The global pattern of somatic variation in the kinase set is not significantly different from random for the locus- and gene-level observables studied here.

Two groups of kinase outliers were observed.

Figure 7 Taxonomies of kinase subsets.