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Quantitative variation of histone marks among S. cerevisiae strains is abundant and complex.
We report on the extent and pattern of intra-species quantitative variation of histone modifications in the epigenome of S. cerevisiae.
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Additional file 27: Similar co-variation of histone marks at isolated vs. regional SNEPs.
Such a partial co-variation of histone marks and mRNA levels was also observed when clustering genes on the basis of their epigenomic differences between the BY and YJM strains.
We sought to establish a method to assess the variations of histone modifications across cellular differentiation states.
These higher variations of histone modifications corresponding to hematopoietic-specific TFs represent dramatic chromatin state changes leading to the activation or repression of certain genes.
Zia and Graham/Bryce have a pair of papers out in Science today: evolution of protein expression in primates and effects of genetic variation on histone modifications.
There's a nice perspective in NRG by Hannah Storey on 4 recent papers--including one by Graham and Bryce--that studied the effects of genetic variation on histone mods.
Therefore peak widths reveal the positional variation of the histones on the DNA subject to experimental noise such as incomplete digestion by the MNase enzyme.
The authors correctly emphasize the large negative impact of the batch-to-batch variation of anti-histone PTM antibodies and its consequence ('large data sets in chromatin biology exist in a "grey" area outside of natural science, since it is impossible to repeat the underlying experiments.').
Epigenomics is defined here as genomic-scale studies of chromatin regulatory variation, including patterns of histone PTMs, DNA methylation, nucleosome positioning and long-range chromosomal interactions.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com