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Table 1 shows the transmural variation of collagen fraction across all hearts.
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The structural changes of collagen due to misfoldings of the triple helices can be associated with severe diseases [ 2], so it is important to study those variations of collagens in tissues.
Planar collagen membranes (CMs) of 0.1 5.3 μm dry thickness were made by variation of the collagen concentration and/or the volume of the hydrogel.
Site-specific variation of the collagen network moduli, PG matrix modulus and permeability was analyzed.
There was some variation in the collagen array layer by layer, but no variation in entropy of collagen alignment (p = 0.45).
Further research is required to confirm an association between genetic variation, of genes encoding collagen proteins and proteins involved in pathways of tendon homeostasis and Achilles tendinopathy.
RV fibrosis in response to increased afterload has been reported in some PH models [ 28, 34, 60] as well as in PAB models [ 17, 28], although there is a wide variation in the amount of collagen measured across models and the timeframe in which it develops.
Variations in percent mammographic density (PMD) reflect variations in the amounts of collagen and number of epithelial and non-epithelial cells in the breast.
This hypothesis is supported by published data showing that no variations in transcription level of collagen were observed following supplementation of cell culture medium with ibuprofen [ 33].
In other ultrastructural studies of disc tissue, we have reported considerable variation in cross-sectional diameters of collagen fibrils in both territorial and inter-territorial extracellular matrix [ 8].
The model predicted a lot of variability in the levels of active MMPs and, hence, variation also in the percentage of collagen released by day 14 (see Supplementary Figure 6).
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