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Further, cluster analysis does not provide any information on the amplitude variation of clusters in time.
The proposed index adopts a compactness measure to describe the variation of clusters, and introduces the fuzzy separation concept to determine the isolation of clusters.
Various problems which may occur in each step of the sample preparation and sequencing can be detected by an analysis of the variation of clusters density; base-call proportions; and base quality across cycles of the run, and across tiles and lanes of the flow cell.
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The experimental results confirm the variation of cluster-size distribution.
The variation of cluster index with K value is shown in Fig. 4.
If this was the case, the scattering band ratios in Figs. 4 and 5 would partially reflect the variation of cluster sizes in these sources.
Since the distance function is not suitable for categorical data, we employ the variation of cluster purity (calculated by rough entropy) to instead of parameter ε (Eps).
The variation of cluster profiles with different thresholds also reveals that there is a solids holdup gradient inside the cluster with a lower value at the surface and a higher one in the core.
For unequal sized clusters: where cv is the coefficient of variation of cluster sizes.
A number of these approaches involve some variation of clustering analysis, which can have important limitations.
The variation of cluster sizes has little effect on the type I error rates when the number of clusters achieves 30.
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