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The stromal interacting protein 1 (STis1) is an ER resident protein that detects variation of calcium in the ER.
The variation is mainly due to variation of calcium content.
The most common patterns of variation of calcium in one cell are characterized by the following qualitative features.
To study signal transduction elicited by MGs for magnetoreception, the variation of calcium ion in trophocytes and fat cells labeled with flou 4 were measured under confocal microscope.
Under these conditions, neurons cultured from WT and DAP12KI P0 displayed similar activity (coefficient of variation of calcium fluctuation in DAP12KI cultures: 115±4% of WT; Fig 2A).
Yet, in the presence of 6-cyano-7 nitroquinoxline-2 (CNQX), an AMPAR antagonist, neuronal activity was significantly lower in neurons cultured from mutant as compared with WT littermates (coefficient of variation of calcium fluctuations in DAP12KI cultures: 66±2% of WT; n>600; p<0,0001; Fig 2B).
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61 In this intricate system, damage of one protein such as Pmc1p or Vcx1p may not affect cell's ability to adjust to small variations of calcium burst.
Variations of calcium, phosphate and casein concentrations in milks, both within and among species, are mainly due to the formation of the nanocluster complexes.
This study compares the variations of calcium-bound P and iron-bound P with the independent proxy for biologic production proxy Total Organic Carbon (TOC) as well as a climatic proxy for lake level fluctuation from the borehole.
To study the long-term variations of chloride, calcium, and sulfate concentrations in the lake, more than 30 years of measured data (SFWMD, [2011]) was analyzed.
However, at variance with ERAD substrates and bacterial toxins, we propose that CRT retrotranslocation is modulated by structural modifications triggered by variations of ER calcium levels.
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