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Begg CB, Haile RW, Borg A, et al. Variation of breast cancer risk among BRCA1/2 carriers.
Semi-automated analysis of breast density reduces inter-observer variation of breast density classification on mammograms.
Overall there was no significant variation of breast cancer risk with dose (P>0.5).
Residences at birth and before age 21 years were grouped into eight broad geographic regions based on the geographic variation of breast cancer mortality as shown in the NCI's Atlas of Cancer Mortality [ 15].
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The variation of breast-cancer risk with childbearing, observed in clinial studies, seemed best regarded as a second gradient of risk, seen more readily as variation of breast-cancer rates within a population, where differences in diet would be relatively small.
However, this correlation was not independent of the correlations with diet, and it was concluded that variation of breast-cancer rates between countries arose predominantly from differences in diet.
A second study out of Laval University in Quebec sought to assess seasonal variations of breast density, a biomarker of breast cancer risk.
When a four-month lag time was assumed, seasonal variations of breast density and circulating vitamin D appeared to be highly synchronized, so much so that "variations of breast density appeared to be a mirror image of those of 25(OH D," the researchers wrote in the May 2007 issue of Cancer Epidemiology Biomarkers & Prevention.
The increasing incidence and geographic variation of human breast cancer has begun to focus attention on the etiologic potential of other environmental factors (Coyle 2004).
The two-stage model implies that others exist and that they are responsible for both the international variation in risk of breast cancer, and its familial aggregation.
Early studies of mother-daughter sets [ 110, 111] and small twin studies [ 111, 112] suggested that genetic factors might explain a proportion of the variation (the heritability) of breast tissue patterns within a given population.
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