Sentence examples for variation linkage from inspiring English sources

By relating phenotypic and genetic variation, linkage and association mapping allow us to identify the genetic basis of complex traits (Mackay et al. 2009).

These EST-SSRs have been applied successfully in studies of genetic variation, linkage mapping, gene tagging, evolution and sequencing of several plant genomes [ 21].

Based on the genotype data of the genetic variations, linkage disequilibrium (LD) analyses and a haplotype-based case control study were carried out using the expectation maximization algorithm with the SNPAlyze software program ver3.2 (Dynacom, Yokohama, Japan).

Despite these variations, linkage of MHC genes is thought to provide functional advantages via co-evolution of genes, generation of diversity and co-ordination of expression and function [ 12].

In general, extensive variation of linkage types does not occur within a polysaccharide structure, nor are there many polysaccharides composed of more than three or four different monosaccharides; most contain one or two.

Studies of copy-number variation and linkage disequilibrium (LD) have typically excluded complex regions of the genome that are rich in duplications and prone to rearrangement.

Our findings establish disturbed connectivity as a neurogenetic risk mechanism for psychosis supported by genome-wide association, show that rs1344706 or variation in linkage disequilibrium is functional in human brain, and validate the intermediate phenotype strategy in psychiatry.

Human studies have also benefited from an alliance between statistical methodology applied to genomic variation and linkage studies and genome-wide association studies (GWAS) are beginning to make progress in identifying the polygenic nature of complex human behavioral traits.

The effect of variation in linkage on the release of fluorophore has been studied by the analysis of spectroscopic properties, temperature and pH stability, kinetics and concentration-dependency of the probes during NTR reaction.

"Flip-flop" associations might additionally arise from variation in linkage disequilibrium structure in the genomic region of interest between the cohorts in different studies.

This notion is corroborated by a recent study that studied genome partitioning of genetic variation using linkage data from over ten thousand sib pairs and found that most chromosomes could harbor loci that affect human height[10].