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In insect societies, intracolonial genetic variation is predicted to affect both colony efficiency and reproductive skew.
Finally, we identify SNPs at which variation is predicted to influence binding of these TFs.
The approach requires assignment of candidate cell types to candidate genes and identifies potentially causal (non-coding) SNPs at which variation is predicted to influence transcription factor binding.
The c.6424+1G>T variation is predicted to lead to an abolishment of the donor splice site located at this position.
We therefore developed an approach to prioritize candidate regulatory mechanisms, which provides a rank-ordering of potentially causal non-coding SNPs at which susceptibility-associated variation is predicted to influence TF binding in specific cell types.
Substantial genetic differences exist between the Black Angus and Holstein animals sequenced in this work and the Hereford reference sequence, and some of this variation is predicted to affect evolutionarily conserved amino acids or gene copy number.
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The vast majority of the observed variation was predicted to have no impact on the efficaciousness of a protein vaccine incorporating a single variant of SP0148, SP1912 and/or SP2108 from S. pneumoniae TIGR4.
Multiple allelic variants of these proteins were identified, different allelic variants dominated in different continents; the observed variation was predicted to impact the antigenicity and structure of two SP0148 variants, one SP1912 variant and four SP2108 variants, however these variants were each only present in a small fraction of the global population (<2%).
This yielded SNP-motif pairs for which genetic variation was predicted to influence TF binding.
Genetic variation was predicted to occur along latitudinal and elevation gradients (Figs 1C and S6B).
In the shallow part of the conduit (< 1 km), magma pressure variations are predicted to be less than tens of MPa from the lithostatic pressure.
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