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These subjects where the notion of p-adic variation is involved are advancing very quickly and a substantial breakthrough is expected in the near future.
It is widely hypothesised that the predisposing variation is involved in cis-regulation of TCF7L2 activity.
Together, this shows sensory systems vary considerably across populations and supports the possibility that sensory system variation is involved in population divergence of mate preference.
Given the diversity of alternate phenotypes that may be generated by the 69 HPTs identified in this study, it is likely that phase variation is involved in many aspects of Bordetella pathogenesis.
In this study, we wanted to look at the nucleotide and amino acid sequence variation in the HPV16 E2 gene and to test the hypothesis that sequence variation is involved in disease progression.
For example, an amino acid substitution between two alleles that vary along a cline in temperature affects thermostability [ 8], and experimental studies have shown that this variation is involved in the adaptation of killifish to hypoxia [ 9, 10].
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Maximum-likelihood estimation was straightforward in this case, because no end point to end point variation was involved.
In this study, we wanted to elucidate whether SLC6A4 variations is involved in attempted suicide among patients with schizophrenia in a Scandinavian case control sample.
In addition, identifying which variations are involved in altering responses to drugs could facilitate the development of personalized medicine.
However, a growing body of evidence has shown that epigenetic mutations, especially methylation variations, are involved (Kaeppler et al. 2000; Matthes et al. 2001; Xu et al. 2004; Peredo et al. 2006; Bednarek et al. 2007; Schellenbaum et al. 2008).
Study I was conducted under the most controlled conditions, whereas Study III was closest to a real experiment where almost all sources of variations were involved.
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