We demonstrate significant enrichment of common variants associated with orofacial clefting in enhancers active early in embryonic development, while those associated with normal facial variation are enriched near the end of the embryonic period.
We further established that genes subjected to significant purifying selection opposing CpG variation are enriched for disease association.
In our second set of analyses, we were interested in whether genes with the greatest or least amount of variation were enriched for any GO terms.
In all categories of CNVs, pathogenesis, rosetting, cell-cell adhesion, cytoadherence to microvasculature and antigenic variation were enriched, as expected, due to preponderance of polymorphic gene families among the CNV regions.
Average variability inside MCRs was 1.51×10-3, somewhighergher than MCR windows but outside MCRs boundaries (9.09×10-4), windows windevoidevofd of MCRs had the lowest average diversity (8.42×10-5), suggesthat that windows with high nucleotide variation are enriched in MCRs (Summary statistics in Table 4).
These breast cancer patients originate from the Oulu region of Northern Finland and the 3′ UTR+60 bp G>C change might represent a variation that is enriched in this population, as it was also observed in three healthy controls.
Together, these results show that at the genomic level, variation between local populations is enriched for the gene classes fbox, math, bath, btb, clec, serpentine chemoreceptor, and nhr, many of which are involved in gene-environment interactions [ 42- 45].
The heart-green module (898 genes) is enriched for these genes and shows a pattern of within-mouse variation with little between-mouse variation (c = 0.00).
Cluster V is enriched with the yeasts that were more resistant to temperature variations and H2O2 but had an average resistance to NaCl and acetic acid.
"Life is enriched by difficulty," he says.
