Next, we tested whether the hypothalamic orexigenic and anorexigenic genes responded properly to variations in the peripheral energy balance in BBS mice by comparing the mRNA levels of these neuropeptides in normally fed and 48 h fasted animals.
These studies show that great variation exists in the peripheral and central mechanisms for extraction of important target features such as direction, azimuth, elevation, velocity or size that are used for related orientation behaviors.
The observed seasonal variation in the incidence of peripheral facial palsy caused by LNB, with a peak in late summer/early autumn and no cases during late winter/early spring, confirms previous studies and co-varies with the tick-feeding season.
In contrast, such variations in expression in the peripheral, nonhub nodes associated with lineage-specific and developmental functions may have been relatively tolerant in the context of cell survival.
They have also been used recently to investigate variation in gene expression in the peripheral blood leukocytes of normal individuals (Whitney et al. 2003).
In this report we propose measuring cell-to-cell variations of gene expression in the peripheral blood sample taken from a given individual.
A strength of our study is that all of our findings replicate in two phases, and we have performed careful normalization using two parallel modes of analysis to confirm the results and relate them to our prior evaluation of the axes of variation in human peripheral blood.
Specifically, Kellis and his collaborators Alexander Meissner and Brad Bernstein from Harvard will work to characterize the epigenomic effects of genetic variation in nine peripheral tissues with roles in diabetes, heart disease, and cancer.
Variation in the gene expression of circulating peripheral blood mononuclear cells (PBMCs) from three healthy volunteers sampled three times one day each week for one month was examined for 1,176 genes printed on filter arrays.
Studies in peripheral blood and in liver indicate that this functional polymorphism accounts for most of the human variation in peripheral COMT activity.
