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Both the variables included and the analytic techniques used may lead to variation in the associations detected in big data studies (Abrams et al. 2008; Fan et al. 2014; Patel et al. 2015a).
We treated the within-state effect as a random effect in the model to permit state-level variation in the associations between relative changes in unemployment rates and state-level prescription rates.
Alternatively, the observed variation in the associations for childhood body fatness could be explained by age differences between participants in the two cohorts (NHS: mean age=54.3 in 1988, NHSII: mean age=34.3 in 1989); therefore, we conducted a preliminary analysis combining both cohorts and stratifying by age, while adjusting for menopausal status.
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A variation in the association between EBV-associated gastric carcinomas and ethnicity according to birth year was evaluated by tests for interaction.
There was considerable variation in the association between year of birth and height across countries (Table 6).
The variation in the association we observed by subtype suggests possible differences in RCC aetiology.
The above-mentioned argument also might account for the observed seasonal variation in the association.
Even after we accounted for these differences, the racial variation in the association between blood pressure and incident diabetes persisted.
These findings could indicate a geographical variation in the association between air pollution and low birth weight.
Further, we did not observe any significant variation in the association of parity with diabetes between blacks and whites.
Allowing for year-to-year variation in the association between influenza activity and mortality also improved model fit.
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