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To assess variation in processes of care, we used the Index of Qualitative Variation (IQV).
In the literature, BPS is predominantly conceptualized as the unification or homogenization of process variants (Beimborn et al. 2009), acknowledging local variation in processes as inevitable and necessary (Tregear 2015).
Measuring the process was a prerequisite for becoming aware of variation in processes and implementing measures to eliminate it.
The objective of this study was to investigate diurnal variation in processes that regulate drug concentrations in the brain, focusing on P-glycoprotein (P-gp).
Therefore, the greatest variation in processes, such as gastric emptying, gastrointestinal motility, and gastric acid secretion, could be expected between morning and evening.
For example, incident reporting, clinical auditing and quality improvement approaches such Statistical Process Control all identify, and aim to resolve, 'defects' or unacceptable variation in processes.
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The variation in process parameters reflected changes in crystallinity, optical properties, surface morphology, functional groups and other vital physicochemical properties.
This choice was motivated by the variation in process related market parameters and their impact on profitability.
Since variation in process time and process output is commonly accepted to be inevitable for biological processes, application of Process Analytical Technologies PATT) on these processes is challenging.
Furthermore, the proposed input topology makes the device robust in terms of its performance over variation in process, voltage and temperature.
To achieve this goal, several methods have been used, primarily in screening for enzymes from new sources, enzyme improvement, substrate structure modification, medium engineering, and variation in process parameters.
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