Variation in mechanisms of resistance has implications for the choice of antimicrobial therapy and the evaluation of strategies to minimize resistance.
It should be noted that other components of the HPA axis such as binding proteins that transport corticosteroids in blood, and receptors and metabolizing enzymes in the target tissues, also provide potential for individual variation in mechanisms of modulation (e.g. Wingfield, 2012, Wingfield, 2013a, Wingfield, 2013b; Fig. 4).
However, the subtle structural differences that have recently been observed across a variety of families shed light on their functional diversity, including variations in mechanism of action, differences in the modes of substrate binding, and substrate-assisted orientation of catalytic residues.
The resulting microstructures of the films correlate to dominant variation in mechanical properties and deformation mechanisms.
We found variations in mechanisms and activities at injury with age, and over time.
This suggests the presence of certain developmental constraints, which set a limit on variations in mechanisms of neurogenesis even in basal deuterostomes, such as echinoderms.
Variations in mechanisms among different species, effects of culture conditions and differences in ages of the animals may explain these differences.
Normal kinematic joint can be transformed to variable kinematic joint VKJ), which refers to a kinematic joint that is capable of topological variation in a mechanism, by utilizing effect of friction and self-locking.
There was great variation in the mechanism of failure.
Nevertheless, nucleosome turnover was highly variable at low levels of elongating PolII density, indicating that there is significant gene-to-gene variation in the mechanism of PolII transit through nucleosomes at low rates of transcription.
