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Genetic variation in egg mass or pupal mass did not contribute to variation in lifespan.
A haplotype of two markers in the Lim3A regulatory region was significantly associated with variation in lifespan.
The eight wild mth lines showed phenotypic variation in lifespan in both the mthΔ6 and the mth1 complementation tests (Table 1).
Thus considerably more variation in lifespan was attributable to mitochondrial rate variation than had been estimated previously (below 20 percent in [21]).
Our results demonstrate that natural variants of mth, a gene for aging in Drosophila, contribute to significant functional variation in lifespan, fecundity and resistance to oxidative damage.
Since different laboratory isolates can exhibit variation in lifespan [23], we conducted parallel longevity assays on our isolates of C. elegans N2, C. briggsae AF16, C. remanei EM464 and C. brenneri CB5161.
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That is, relative to the lifespan experiments, seasonal variation in lifespans appears to be magnified if measured inside the lumen (i.e. 20/11 is only 1.85).
These data were pooled across years to yield monthly means, which were transformed to lifespan estimates using the model fitted to the laboratory data (Figure S3), and we then grouped the months into two seasons by minimizing the sum of the within-season coefficients of variation in lifespans: Min[CV(Summer lifespans) + CV(Winter lifespans)].
3 5 Progress in reducing premature deaths reduces variation in lifespans, whereas progress in reducing deaths at older ages increases variation in lifespans.
Annual fish of the genus Nothobranchius show large variations in lifespan and expression of age-related phenotypes between closely related populations.
Captive populations of N. furzeri show reproducible variations in lifespan and expression of age-related histological traits, including lipofuscin accumulation and apoptosis [ 15].
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