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Exact(5)
Other variables (gender, age, ethnicity, wealth) showed species- and area-level variations, and we observed substantial spatial variation in expressed attitudes towards species.
However, a combination of genes, each with minor variation in expressed activity, could provide a degree of separation of risk that would be clinically useful.
To illustrate the feasibility of identifying sequence variation in expressed genes, we focused on the known single nucleotide mutation in SCD in which glutamic acid-6 is replaced by valine (GAG replaced by GTG).
The distribution of ESTs across the six individual libraries (larvae, nymph, adult male, adult female, engorged female, and wild-collected) allowed examination of variation in expressed genes across developmental stage.
To illustrate the feasibility of identifying sequence variation in expressed genes, we visualized the sequence of reads from the beta globin gene (DNAnexus, https://dnanexus.com/) for SCD and control subjects in the neighborhood of the known single mutation driving sickle cell disease.
Similar(55)
RNA-seq gene expression patterns provided also information on complex regulatory networks and on variations in expressed genes, such as SNPs and SSRs, in an increasing number of non-model plants [ 45] and thus may be well suited to overcome the bottleneck of lacking genomic resources in Lathyrus.
RNA-seq is an attractive method that enables the identification of sequence variations in expressed transcripts.
Another key advantage of RNA-seq over existing technologies for transcriptomic studies is its ability to identify sequence variations in expressed transcripts.
Thus, RNA-seq represents more than 15-fold enrichment when compared to DNA-sequencing at equal read counts and therefore provides a much more efficient method for identifying sequence variations in expressed soybean seed genes.
In the thalamus the α4β2 nAChR is the only expressed nicotinic receptor [34] with some variation in the expressed distribution of the α and β subunits.
However, they lack the power to detect variation in weakly expressed, tissue-specific genes or genes that show opposing changes in expression between tissues.
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