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To understand the dynamics of in vivo antigenic variation among the parasite population it is necessary to have sensitive and broadly applicable tools enabling monitoring of variation events in parasite antigen genes.
These common variations represent the lower boundary of variation events in A. gambiae because the intersection of two sets also removed many true positive TSVs.
To illustrate this improved sequencing method, Dr. Ragoussis presented data from his lab, showing newly identified copy number variation events in patients with autism.
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Although the somatic variants discovered from our study appear to be distributed uniformly across the genome, the significant copy number variation events are more concentrated in chromosomes 6 9 and 11.
In ovarian cancer, it detected mutually exclusive variation events between BRCA and genes in the Rb module.
As shown in the lower panel of Fig. 1, 41% of the variation events were intron retention (IntronR), 10% were alternative acceptors (AltA), 14% were alternative donors (AltD), 11% were alternative donors and acceptors (AltS), and only ∼6% of variation events were exon skippings (ExonS) in A. gambiae.
The use of non-parametric time-series models allowed for the adjustment of temporal changes such as seasonal, long, and short-term variations of events in the classified area.
(b) Phase angle frequency variation for seismic events in the period 1800 days before the Wenchuan M 8.0 earthquake.
(c) Phase angle frequency variation for seismic events in the period between 2300 to 11000 days before the Wenchuan M 8.0 earthquake in Subregion 1.
Fig. 6 (a) Phase angle frequency variation for seismic events in the period 1600 days before the Wenchuan M 8.0 earthquake in Subregion 2. The fine solid curve denotes a function of sinusoidal least squares fit to the variation.
(c) Phase angle frequency variation for seismic events in the period between 1600 to 11000 days before the Wenchuan M 8.0 earthquake in Subregion 2. The fine solid curve denotes a function of sinusoidal least squares fit to the variation.
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